If you’ve been struggling with depression for a long time, despite trying various treatments, you might be experiencing what is known as treatment-resistant depression (TRD). Living with treatment-resistant depression can feel like an uphill battle. For many people, traditional antidepressants and talk therapy simply aren’t enough. When depression doesn’t improve with standard treatment methods, it’s easy to feel discouraged or stuck.
TRD refers to cases where an individual’s depression does not improve after trying at least two different antidepressant medications for a sufficient period. If you find yourself feeling stuck despite medication, therapy, and lifestyle changes, it may be time to explore other options, such as Spravato, TMS, or other advanced therapies.
Spravato, the brand name for esketamine, is a prescription nasal spray approved by the FDA for adults with treatment-resistant depression. It works differently than conventional antidepressants and has been shown to deliver fast-acting relief when other options have failed. Unlike medications that can take weeks to show results, Spravato begins working within hours to days for some individuals, helping to lift the emotional weight that’s been holding them back.
If you or someone you love is battling depression and nothing seems to work, it might be time to consider Spravato®. It's not the first line of defense, but for treatment-resistant depression or immediate mental health treatment, it can be a lifesaver. The first step is a consultation with your provider. Visit https://wilshireinstitute.com/spravato/ for more information on Spravato® depression treatment. You can also call or text us at (310) 598-6600. Help may be closer than you think.
What Makes Spravato Depression Treatment Different?
Spravato depression treatment targets the NMDA receptor in the brain, which affects the glutamate system in the brain and is involved in mood regulation and thought processes. Traditional antidepressants and other medications primarily affect the levels of serotonin, dopamine, or norepinephrine in the brain. Thus, Spravato affects different pathways and it is why it is considered an alternative for those who do not necessarily respond to medications and treatments that are common. Additionally, Spravato treatments have shown to allow individuals to be more receptive to therapeutic work in conjunction with therapy and processing their emotions. Many patients notice a significant shift after just a few treatments, often describing a reduction in emotional heaviness or an improved ability to function in daily life.
This innovative therapy is administered in a clinic setting, where patients self-administer the nasal spray under the supervision of a trained professional. After treatment, patients remain in the clinic for a 2-hour monitoring period designated by the FDA-regulations, to ensure safety and manage any side effects.
A mental health psychiatrist will determine if you’re a good candidate for Spravato based on your mental health history, previous treatment attempts, and current symptoms. It’s typically recommended for adults who have tried at least two other antidepressants without adequate relief.
What to Expect During Treatment
Each session begins with your psychiatrist or clinical team reviewing your symptoms and checking for any medical concerns. After administering the nasal spray, you’ll be closely monitored in a calm, comfortable environment. You may experience some dizziness, sedation, or dissociation, which typically resolve naturally throughout the appointment and disappear completely within a couple of hours. Sessions start twice a week, then taper down as your symptoms improve.
Is Spravato Right for You?
If you’ve been battling depression for years and have tried multiple treatments without success, Spravato depression treatment may be the option that changes everything. It’s particularly effective for people experiencing intense symptoms, suicidal thoughts, or emotional numbness that traditional medications haven’t resolved.
Individuals with Treatment-Resistant Depression (TRD) are the primary group that benefit from Spravato nasal spray. To be diagnosed with TRD you must already have a diagnosis in Major Depressive Disorder (MDD). MDD that does not respond to at least two different oral antidepressant medications would then be considered treatment-resistant. Not responding can be different for individuals: either over a period of time (around 4-6 weeks) there are no changes to symptoms or adverse side effects that cause medication shifts can be considered non-responsive. If you are interested in knowing more about treatment-resistant, it is important to speak with your current mental health provider. Or, reaching out to Spravato centers, such as Wilshire Center, can help coordinate consultations with a psychiatrist to address your specific history and create unique treatment plans that fit your needs.
Spravato nasal spray for depression offers a faster-acting alternative when compared to traditional antidepressants that can take several weeks to show noticeable improvement. Studies have shown noticeable improvement in symptoms as early as the first 24-48 hours after the first treatment. Spravato nasal spray has thus been an attractive option for individuals who have found no relief from traditional medication and feel hopeless after trying numerous treatments with little success.
When it comes to seeing if you’d benefit from adding Spravato into your treatment, a mental health psychiatrist will guide you through the evaluation process, discussing your history, concerns, and goals. Together, you’ll develop a plan that prioritizes your well-being and safety while offering a realistic path to recovery.
Take the Next Step Toward Healing
Living with treatment-resistant depression can feel like there’s no way forward—but there is. Spravato depression treatment offers a scientifically-backed, fast-acting alternative that may finally bring relief. If you’ve tried other options without success, it may be time to explore this breakthrough therapy. Schedule a consultation with a qualified mental health psychiatrist to see if Spravato is right for you. Taking this step could be the beginning of real, lasting change. At Wilshire Institute for Interventional Psychiatry, we specialize in Spravato and provide a holistic approach to empower individuals on their mental health journey. We create personalized treatment plans that include lifestyle modifications and expert care, helping patients build resilience, achieve emotional balance, and enhance overall vitality for lasting wellness.
If you or someone you know is struggling with treatment-resistant depression do not hesitate to reach out for support. For many, Spravato offers a much-needed breakthrough and a chance to finally reclaim joy and function in daily life.
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